Minding the scientific skeleton in the closet

Categories: guest blogger
Comments: No Comments
Published on: October 22, 2013

Two weeks ago, Pamela Roland from UC Davis retracted a Science paper originally published in 2009. She gave her perspective on the events leading to the retraction in a Scientific American blog post. Here a post-doc in her lab gives his side of the story, emphasising the importance of teamwork, honesty, and willingness to speak up at every level of the academic hierarchy.

Benjamin Schwessinger obtained his PhD at The Sainsbury Laboratory, under GARNet Advisory Committee member Cyril Zipfel. He joined Pamela Roland’s UC Davis group in 2011. This post is an edited version of DO mind the scientific skeletons in the closet, originally published on the blog he co-hosts with Ksenia Krasileva, a postdoctoral fellow in Jorge Dubcovskey’s lab.

 

Yet another Science paper retracted today. Nothing much new unfortunately – except that for me and my colleagues this was not just another example of non-reproducible work. We planned our research projects around it. So here are my thoughts about this, and just in time for Halloween.

There has been much talk about the problem of reproducibility of data and the rise in retractions. The discourse is mostly centered around the perpetrators and the negative impact this sloppy or knowingly flawed science has on the industry and the perception of scientific endeavor in society: Who did this awful study? What reviewer did not catch this missing control, the sloppy stats? Why don’t they admit their mistake? What’s wrong with peer-review? Well, much is wrong with the industry, and many people have great ideas about how to tackle some of these issues.

What is usually missed from the discussion is the impact such dubious science can have on young, early career scientists. What do you do if you come to a famous (or not so famous) lab, you get a project, which is based on fantastic data and high impact publications, but you cannot reproduce it? How do you approach this issue? What does it mean for you and your career if your project goes to shreds because it’s based on bad data? Do you get another chance? Will you be forever associated with this flawed data and your reputation damaged? Will you get so disillusioned with science to the point that you leave academia? Do you try to fix the problem or silently move on? Do you tell the boss and explain your situation? Or is it you? Can you just not get it to work? Can it really be that this is all wrong? Why cannot I reproduce this data? And the questions go on and on … I think everyone can appreciate the complexity of the issue. Many people I talked to had their own experience to share.

Here is what’s frightening:  sloppy science and misconduct, I thought, is something you read about in journals and not something I would experience myself. This would never affect me or close friends in other labs, who are all great scientists in my eyes. I was wrong. (more…)

Traditional varieties are key to modern rice farming

Analysing root growth and yield of rice plants.

Highlighted article: Rico Gamuyao, Joong Hyoun Chin, Juan Pariasca-Tanaka, Paolo Pesaresi, Sheryl Catausan, Cheryl Dalid, Inez Slamet-Loedin, Evelyn Mae Tecson-Mendoza, Matthias Wissuwa & Sigrid Heuer (2012). The protein kinase Pstol1 from traditional rice confers tolerance of phosphorus deficiency. Nature 488, 535–539 doi:10.1038/nature11346

Over centuries, many local rice varieties have been bred into a few modern varieties which are extensively farmed throughout much of Asia. In regions where soil is poor such as western India and Thailand, rice crops are dependent on rainfall, frequently suffering from floods and draughts, and importantly also require phosphorus fertilizer. Phosphorus is an essential plant nutrient, and as phosphorus fertilizer is made from a finite store of phosphorus rock the current situation in the parts of Asia with poor soil is not sustainable.

A solution to this problem was found in a traditional rice variety, Kasalath. Another traditional rice variety has already supplied modern rice breeders with submergence tolerant gene SUB1, which enables rice plants to survive up to two weeks of flooding. A decade ago, a major quantitative trait locus was identified in Kasalath that conferred tolerance to phosphorus deficient soil. This locus was labelled Pup1, and last year the Heuer group at the International Rice Research Institute defined a core set of Pup1 markers and used them to backcross Pup1 into modern rice varieties, which were grown in their natural environments and all produced significantly more rice in P-deficient conditions than their wildtype counterpart. These Pup1 introgression lines also showed improved root growth under stress. (more…)

page 1 of 1

Follow Me
TwitterRSS
GARNetweets
Categories
October 2024
M T W T F S S
 123456
78910111213
14151617181920
21222324252627
28293031  

Welcome , today is Thursday, October 3, 2024